Evaluasi Penggunaan Berbagai Macam Polimer untuk Matriks Penghantaran Obat Secara Transdermal

Abstract

The transdermal patch matrix delivery system can be modified by various of additives so that the drug delivery profile can be controlled. Polymer is a part important in the drug delivery system in transdermal determine and control the rate of release of drug from the reservoir of the drug in the patch transdermal, enables the delivery of drug that is safe, constant, and effectively to the body. This study aims to determine the effect of using various polymers for transdermal drug delivery matrix based on several literatures that have been published in the last 5 years. Research is a literature review. Sources of data using a database of scientific to get the sources relevant to that associated with the use of polymers in the formulation of the matrix patch transdermal. The samples were the articles of research that is associated with the use of polymers in the formulation of the matrix patch transdermal, which published 5 years past and can be accessed free full text. The use of polymers in the formulation of the matrix transdermal patch could affect the physicochemical characteristic of the matrix transdermal patch. Use of ethyl cellulose preferably in combination with polymer hydrophilic such as PVP and HPMC, because the patch become drier and brittle, however the use of PVP and HPMC in the huge amount may affects preparations more moist, thicker and heavier so it will increase patient’s convenience of. The combination of hydrophobic and hydrophilic polymers affected the drug release process from transdermal patch preparation. The addition of polymer hydrophilic was a factor essential to increase the overall solubility. Increasing high concentrations of PVP or HPMC combined with ethylcellulose and concentration eudragit®RL 100 combined with eudragit®RS 100 would increase the release profiles of the drug.